Value of (1-3)-β-d-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

E. Mokaddas; Z. U. Khan; S. Ahmad; M. R.N. Nampoory; M. Burhamah

doi:10.1111/j.1469-0691.2011.03608.x

Value of (1-3)-β-d-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

E. Mokaddas, Z. U. Khan, S. Ahmad, M. R.N. Nampoory, M. Burhamah

Kuwait University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

This study determined the value of (1,3)-β-d-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n=16), C. tropicalis (n=10), C. parapsilosis (n=7), C. glabrata (n=3) and C. dubliniensis (n=3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.

Original language	English
Pages (from-to)	1549-1553
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	17
Issue number	10
DOIs	https://doi.org/10.1111/j.1469-0691.2011.03608.x
State	Published - Oct 2011

Keywords

(1-3)-β-d-glucan
Candida DNA
Candida mannan
Candidaemia
Diagnosis

Funding Agency

Kuwait Foundation for the Advancement of Sciences

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10.1111/j.1469-0691.2011.03608.x

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title = "Value of (1-3)-β-d-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia",

abstract = "This study determined the value of (1,3)-β-d-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n=16), C. tropicalis (n=10), C. parapsilosis (n=7), C. glabrata (n=3) and C. dubliniensis (n=3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.",

keywords = "(1-3)-β-d-glucan, Candida DNA, Candida mannan, Candidaemia, Diagnosis",

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AU - Khan, Z. U.

AU - Ahmad, S.

AU - Nampoory, M. R.N.

AU - Burhamah, M.

PY - 2011/10

Y1 - 2011/10

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AB - This study determined the value of (1,3)-β-d-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n=16), C. tropicalis (n=10), C. parapsilosis (n=7), C. glabrata (n=3) and C. dubliniensis (n=3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.

KW - (1-3)-β-d-glucan

KW - Candida DNA

KW - Candida mannan

KW - Candidaemia

KW - Diagnosis

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Value of (1-3)-β-d-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

Abstract

Keywords

Funding Agency

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