The role of Raf kinase inhibitory protein in inflammation

Steve Shenouda; Mira Bosso; Rasheed Ahmad; Fahd Al-Mulla

doi:10.1016/B978-0-12-819612-0.00016-X

The role of Raf kinase inhibitory protein in inflammation

Steve Shenouda, Mira Bosso, Rasheed Ahmad, Fahd Al-Mulla

Dasman Diabetes Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The growing interest in the Raf kinase inhibitory protein (RKIP) is leading investigators to expand their purview to include its dynamic role in inflammation. While much of the current research on RKIP has been focused on cancer, parallel progress is being attained in relation to its impact on inflammation. Inflammation is a pathological process that is involved in the development, behavior and outcome of many diseases and conditions including cancer. This chapter provides a general review on the role of RKIP in key inflammatory signaling pathways and its ramifications on diseases associated with inflammation.

Original language	English
Title of host publication	Prognostic and Therapeutic Applications of RKIP in Cancer
Publisher	Elsevier
Pages	297-322
Number of pages	26
ISBN (Print)	9780128196120
DOIs	https://doi.org/10.1016/B978-0-12-819612-0.00016-X
State	Published - 5 Feb 2020

Keywords

Cancer
GPCR
Inflammation
MAPK
NF-κB
PEBP
RKIP
Raf kinase inhibitor protein
Review
Signaling pathway

Funding Agency

Kuwait Foundation for the Advancement of Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-819612-0.00016-X

Cite this

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abstract = "The growing interest in the Raf kinase inhibitory protein (RKIP) is leading investigators to expand their purview to include its dynamic role in inflammation. While much of the current research on RKIP has been focused on cancer, parallel progress is being attained in relation to its impact on inflammation. Inflammation is a pathological process that is involved in the development, behavior and outcome of many diseases and conditions including cancer. This chapter provides a general review on the role of RKIP in key inflammatory signaling pathways and its ramifications on diseases associated with inflammation.",

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AU - Shenouda, Steve

AU - Bosso, Mira

AU - Ahmad, Rasheed

AU - Al-Mulla, Fahd

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N2 - The growing interest in the Raf kinase inhibitory protein (RKIP) is leading investigators to expand their purview to include its dynamic role in inflammation. While much of the current research on RKIP has been focused on cancer, parallel progress is being attained in relation to its impact on inflammation. Inflammation is a pathological process that is involved in the development, behavior and outcome of many diseases and conditions including cancer. This chapter provides a general review on the role of RKIP in key inflammatory signaling pathways and its ramifications on diseases associated with inflammation.

AB - The growing interest in the Raf kinase inhibitory protein (RKIP) is leading investigators to expand their purview to include its dynamic role in inflammation. While much of the current research on RKIP has been focused on cancer, parallel progress is being attained in relation to its impact on inflammation. Inflammation is a pathological process that is involved in the development, behavior and outcome of many diseases and conditions including cancer. This chapter provides a general review on the role of RKIP in key inflammatory signaling pathways and its ramifications on diseases associated with inflammation.

KW - Cancer

KW - GPCR

KW - Inflammation

KW - MAPK

KW - NF-κB

KW - PEBP

KW - RKIP

KW - Raf kinase inhibitor protein

KW - Review

KW - Signaling pathway

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DO - 10.1016/B978-0-12-819612-0.00016-X

M3 - Chapter

AN - SCOPUS:85092426246

SN - 9780128196120

SP - 297

EP - 322

BT - Prognostic and Therapeutic Applications of RKIP in Cancer

PB - Elsevier

ER -

The role of Raf kinase inhibitory protein in inflammation

Abstract

Keywords

Funding Agency

UN SDGs

Access to Document

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