TY - JOUR
T1 - Risk of mortality among inpatients with COVID-19 and type 2 diabetes
T2 - National data from Kuwait
AU - Al-Ozairi, Ebaa
AU - Brown, Rosemary
AU - Hamdan, Yasmine
AU - Alabdullah, Lulwa
AU - Voase, Nia
AU - Al Kandari, Jumana
AU - Alsaeed, Dalal
AU - Al Ozairi, Abdulla
AU - Hasan, Amal
AU - Al-Mulla, Fahd
AU - Katikireddi, Srinivasa Vittal
AU - Gray, Stuart R.
AU - Gill, Jason M.R.
AU - Celis-Morales, Carlos A.
AU - Sattar, Naveed
AU - Welsh, Paul
N1 - Publisher Copyright:
© 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: To investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait. Methods: A retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction. Results: A total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6). Conclusion: Type 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.
AB - Introduction: To investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait. Methods: A retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction. Results: A total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6). Conclusion: Type 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.
KW - COVID-19
KW - death
KW - diabetes
UR - http://www.scopus.com/inward/record.url?scp=85109395437&partnerID=8YFLogxK
U2 - 10.1002/edm2.287
DO - 10.1002/edm2.287
M3 - Article
C2 - 34505420
AN - SCOPUS:85109395437
SN - 2398-9238
VL - 4
JO - Endocrinology, Diabetes and Metabolism
JF - Endocrinology, Diabetes and Metabolism
IS - 4
M1 - e00287
ER -
