TY - JOUR
T1 - Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico
T2 - an IMI2 SOPHIA study
AU - Al Ozairi, Ebaa
AU - Steenackers, Nele
AU - Pazmino, Sofia
AU - Alattar, Abdulnabi T.
AU - Al Kandari, Jumana
AU - Almeda-Valdes, Paloma
AU - Antonio-Villa, Neftali Eduardo
AU - Delfin, Carl
AU - Faradji, Raquel N.
AU - García-Tuomola A, Aili
AU - Irshad, Mohammad
AU - Longenecker, Joseph C.
AU - Rosen, Jonathan
AU - Hurtado del Pozo, Carmen
AU - Sparsø, Thomas
AU - Lavens, Astrid
AU - Mathieu, Chantal
AU - Van der Schueren, Bart
AU - le Roux, Carel W.
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/11
Y1 - 2024/11
N2 - Background: Individuals with type 1 diabetes (T1D) are traditionally perceived as lean, but recent evidence suggests an increasing trend of obesity. To provide global estimates, this study explored the prevalence of obesity among adults with and without T1D across three distinct global regions. Methods: An observational, cross-sectional study was performed utilizing data from T1D registries and national health surveys to assess the prevalence of obesity (BMI ≥ 30 kg/m2) and the prevalence of overweight and obesity (BMI ≥ 25 kg/m2) across Belgium, Kuwait, and Mexico. Demographic and clinical characteristics of adults with and without T1D were assessed. Prevalence estimates were calculated through a binomial generalized linear mixed-effects model adjusting for age, sex, HbA1c, and survey year. As a sensitivity analysis, propensity score matching was performed for confounder adjustment of age and sex. Findings: The study encompassed 3594 individuals with T1D (from 2003 to 2022) and 9898 without T1D (from 2014 to 2021). After model adjustment for confounders (age, sex, HbA1c% and data-collection year), individual obesity prevalence was lower in individuals with T1D in Kuwait and Mexico than among those without type 1 diabetes (Kuwait: 22% (CI: 18–26%) vs. 44% (CI: 41–48%); Mexico: 5% (CI: 3–7%) vs. 40% (CI: 38–42%)). In contrast, individuals with T1D in Belgium showed a more comparable proportions to those without T1D (12% (CI: 9–16%) vs. 16% (CI:11–22%)). Interpretation: Our data reveal that obesity is prevalent among people with T1D. These findings underscore the need for targeted strategies in T1D care that address the growing concern of obesity. Funding: This manuscript is part of the Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy (SOPHIA) project (www.imisophia.eu). SOPHIA has received funding from theInnovative Medicines Initiative 2 Joint Undertaking under grant agreement No.875534. This Joint Undertaking support from theEuropean Union's Horizon 2020 research and innovation program andEFPIA and type 1 diabetes Exchange, Breakthrough T1D, andObesity Action Coalition.
AB - Background: Individuals with type 1 diabetes (T1D) are traditionally perceived as lean, but recent evidence suggests an increasing trend of obesity. To provide global estimates, this study explored the prevalence of obesity among adults with and without T1D across three distinct global regions. Methods: An observational, cross-sectional study was performed utilizing data from T1D registries and national health surveys to assess the prevalence of obesity (BMI ≥ 30 kg/m2) and the prevalence of overweight and obesity (BMI ≥ 25 kg/m2) across Belgium, Kuwait, and Mexico. Demographic and clinical characteristics of adults with and without T1D were assessed. Prevalence estimates were calculated through a binomial generalized linear mixed-effects model adjusting for age, sex, HbA1c, and survey year. As a sensitivity analysis, propensity score matching was performed for confounder adjustment of age and sex. Findings: The study encompassed 3594 individuals with T1D (from 2003 to 2022) and 9898 without T1D (from 2014 to 2021). After model adjustment for confounders (age, sex, HbA1c% and data-collection year), individual obesity prevalence was lower in individuals with T1D in Kuwait and Mexico than among those without type 1 diabetes (Kuwait: 22% (CI: 18–26%) vs. 44% (CI: 41–48%); Mexico: 5% (CI: 3–7%) vs. 40% (CI: 38–42%)). In contrast, individuals with T1D in Belgium showed a more comparable proportions to those without T1D (12% (CI: 9–16%) vs. 16% (CI:11–22%)). Interpretation: Our data reveal that obesity is prevalent among people with T1D. These findings underscore the need for targeted strategies in T1D care that address the growing concern of obesity. Funding: This manuscript is part of the Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy (SOPHIA) project (www.imisophia.eu). SOPHIA has received funding from theInnovative Medicines Initiative 2 Joint Undertaking under grant agreement No.875534. This Joint Undertaking support from theEuropean Union's Horizon 2020 research and innovation program andEFPIA and type 1 diabetes Exchange, Breakthrough T1D, andObesity Action Coalition.
KW - Obesity
KW - Type 1 diabetes
UR - https://www.scopus.com/pages/publications/85205353660
U2 - 10.1016/j.eclinm.2024.102869
DO - 10.1016/j.eclinm.2024.102869
M3 - Article
AN - SCOPUS:85205353660
SN - 2589-5370
VL - 77
JO - EClinicalMedicine
JF - EClinicalMedicine
M1 - 102869
ER -
