new blood pressure-associated loci identified in meta-analyses of 475000 individuals

Aldi T. Kraja; James P. Cook; Helen R. Warren; Praveen Surendran; Chunyu Liu; Evangelos Evangelou; Alisa K. Manning; Niels Grarup; Fotios Drenos; Xueling Sim; Albert Vernon Smith; Najaf Amin; Alexandra I. F. Blakemore; Jette Bork-Jensen; Ivan Brandslund; Aliki-Eleni Farmaki; Cristiano Fava; Teresa Ferreira; Karl-Heinz Herzig; Ayush Giri; Franco Giulianini; Megan L. Grove; Xiuqing Guo; Sarah E. Harris; Christian T. Have; Aki S. Havulinna; He Zhang; Marit E. Jorgensen; AnneMari Karajamaki; Charles Kooperberg; Allan Linneberg; Louis Little; Yongmei Liu; Lori L. Bonnycastle; Yingchang Lu; Reedik Magi; Anubha Mahajan; Giovanni Malerba; Riccardo E. Marioni; Hao Mei; Cristina Menni; Alanna C. Morrison; Sandosh Padmanabhan; Walter Palmas; Alaitz Poveda; Rainer Rauramaa; Nigel William Rayner; Muhammad Riaz; Ken Rice; Melissa A. Richard; Jennifer A. Smith; Lorraine Southam; Alena Stancakova; Kathleen E. Stirrups; Vinicius Tragante; Tiinamaija Tuomi; Ioanna Tzoulald; Tibor V. Varga; Stefan Weiss; Andrianos M. Yiorkas; Robin Young; Weihua Zhang; Michael R. Barnes; Claudia P. Cabrera; He Gao; Michael Boehnke; Eric Boerwinkle; John C. Chambers; John M. Connell; Cramer K. Christensen; Rudolf A. de Boer; Ian J. Deary; George Dedoussis; Panos Deloukas; Anna F. Dominiczak; Marcus Dorr; Roby Joehanes; Todd L. Edwards; Tonu Esko; Myriam Fornage; Nora Franceschini; Paul W. Franks; Giovanni Gambaro; Leif Groop; Goran Hallmans; Torben Hansen; Caroline Hayward; Oksa Heikki; Erik Ingelsson; Jaakko Tuomilehto; Marjo-Riitta Jarvelin; Sharon L. R. Kardia; Fredrik Karpe; Jaspal S. Kooner; Timo A. Lakka; Claudia Langenberg; Lars Lind; Ruth J. F. Loos; Markku Laakso; Mark I. McCarthy; Olle Melander; Karen L. Mohlke; Andrwe P. Moris; Colin N. A. Palmer; Oluf Pedersen; Ozren Polasek; Neil R. Poulter; Michael A. Province; Bruce M. Psaty; Paul M. Ridker; Jerome I. Rotter; Igor Rudan; Veikko Salomaa; Nilesh J. Samani; Peter J. Sever; Tea Skaaby; Jeanette M. Stafford; John M. Starr; Pim van der Harst; Peter van der Meer; Cornelia M. van Duijn; Anne-Claire Vergnaud; Vilmundur Gudnason; Nicholas J. Wareham; James G. Wilson; Cristen J. Willer; Daniel R. Witte; Eleftheria Zeggini; Danish Saleheen; Adam S. Butterworth; John Danesh; Folkert W. Asselbergs; Louise V. Wain; Georg B. Ehret; Daniel I. Chasman; Mark J. Caulfield; Paul Elliott; Cecilia M. Lindgren; Daniel Levy; Christopher Newton-Cheh; Patricia B. Munroe; Joanna M. M. Howson

doi:10.1161/CIRCGENETICS.117.001778

new blood pressure-associated loci identified in meta-analyses of 475000 individuals

Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, Evangelos Evangelou, Alisa K. Manning, Niels Grarup, Fotios Drenos, Xueling Sim, Albert Vernon Smith, Najaf Amin, Alexandra I. F. Blakemore, Jette Bork-Jensen, Ivan Brandslund, Aliki-Eleni Farmaki, Cristiano Fava, Teresa Ferreira, Karl-Heinz Herzig, Ayush GiriFranco Giulianini, Megan L. Grove, Xiuqing Guo, Sarah E. Harris, Christian T. Have, Aki S. Havulinna, He Zhang, Marit E. Jorgensen, AnneMari Karajamaki, Charles Kooperberg, Allan Linneberg, Louis Little, Yongmei Liu, Lori L. Bonnycastle, Yingchang Lu, Reedik Magi, Anubha Mahajan, Giovanni Malerba, Riccardo E. Marioni, Hao Mei, Cristina Menni, Alanna C. Morrison, Sandosh Padmanabhan, Walter Palmas, Alaitz Poveda, Rainer Rauramaa, Nigel William Rayner, Muhammad Riaz, Ken Rice, Melissa A. Richard, Jennifer A. Smith, Lorraine Southam, Alena Stancakova, Kathleen E. Stirrups, Vinicius Tragante, Tiinamaija Tuomi, Ioanna Tzoulald, Tibor V. Varga, Stefan Weiss, Andrianos M. Yiorkas, Robin Young, Weihua Zhang, Michael R. Barnes, Claudia P. Cabrera, He Gao, Michael Boehnke, Eric Boerwinkle, John C. Chambers, John M. Connell, Cramer K. Christensen, Rudolf A. de Boer, Ian J. Deary, George Dedoussis, Panos Deloukas, Anna F. Dominiczak, Marcus Dorr, Roby Joehanes, Todd L. Edwards, Tonu Esko, Myriam Fornage, Nora Franceschini, Paul W. Franks, Giovanni Gambaro, Leif Groop, Goran Hallmans, Torben Hansen, Caroline Hayward, Oksa Heikki, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Jarvelin, Sharon L. R. Kardia, Fredrik Karpe, Jaspal S. Kooner, Timo A. Lakka, Claudia Langenberg, Lars Lind, Ruth J. F. Loos, Markku Laakso, Mark I. McCarthy, Olle Melander, Karen L. Mohlke, Andrwe P. Moris, Colin N. A. Palmer, Oluf Pedersen, Ozren Polasek, Neil R. Poulter, Michael A. Province, Bruce M. Psaty, Paul M. Ridker, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Peter J. Sever, Tea Skaaby, Jeanette M. Stafford, John M. Starr, Pim van der Harst, Peter van der Meer, Cornelia M. van Duijn, Anne-Claire Vergnaud, Vilmundur Gudnason, Nicholas J. Wareham, James G. Wilson, Cristen J. Willer, Daniel R. Witte, Eleftheria Zeggini, Danish Saleheen, Adam S. Butterworth, John Danesh, Folkert W. Asselbergs, Louise V. Wain, Georg B. Ehret, Daniel I. Chasman, Mark J. Caulfield, Paul Elliott, Cecilia M. Lindgren, Daniel Levy, Christopher Newton-Cheh, Patricia B. Munroe, Joanna M. M. Howson

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results— Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant ( P

Original language	American English
Journal	CIRCULATION-CARDIOVASCULAR GENETICS
Volume	10
Issue number	5
DOIs	https://doi.org/10.1161/CIRCGENETICS.117.001778
State	Published - 2017
Externally published	Yes

Funding Agency

Kuwait Foundation for the Advancement of Sciences

Access to Document

10.1161/CIRCGENETICS.117.001778

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Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A.-E., Fava, C., Ferreira, T., Herzig, K.-H., ... Howson, J. M. M. (2017). new blood pressure-associated loci identified in meta-analyses of 475000 individuals. CIRCULATION-CARDIOVASCULAR GENETICS, 10(5). https://doi.org/10.1161/CIRCGENETICS.117.001778

@article{f9dc91b20542418194064c3bafc2d022,

title = "new blood pressure-associated loci identified in meta-analyses of 475000 individuals",

abstract = "Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results— Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant ( P ",

author = "Kraja, \{Aldi T.\} and Cook, \{James P.\} and Warren, \{Helen R.\} and Praveen Surendran and Chunyu Liu and Evangelos Evangelou and Manning, \{Alisa K.\} and Niels Grarup and Fotios Drenos and Xueling Sim and Smith, \{Albert Vernon\} and Najaf Amin and Blakemore, \{Alexandra I. F.\} and Jette Bork-Jensen and Ivan Brandslund and Aliki-Eleni Farmaki and Cristiano Fava and Teresa Ferreira and Karl-Heinz Herzig and Ayush Giri and Franco Giulianini and Grove, \{Megan L.\} and Xiuqing Guo and Harris, \{Sarah E.\} and Have, \{Christian T.\} and Havulinna, \{Aki S.\} and He Zhang and Jorgensen, \{Marit E.\} and AnneMari Karajamaki and Charles Kooperberg and Allan Linneberg and Louis Little and Yongmei Liu and Bonnycastle, \{Lori L.\} and Yingchang Lu and Reedik Magi and Anubha Mahajan and Giovanni Malerba and Marioni, \{Riccardo E.\} and Hao Mei and Cristina Menni and Morrison, \{Alanna C.\} and Sandosh Padmanabhan and Walter Palmas and Alaitz Poveda and Rainer Rauramaa and Rayner, \{Nigel William\} and Muhammad Riaz and Ken Rice and Richard, \{Melissa A.\} and Smith, \{Jennifer A.\} and Lorraine Southam and Alena Stancakova and Stirrups, \{Kathleen E.\} and Vinicius Tragante and Tiinamaija Tuomi and Ioanna Tzoulald and Varga, \{Tibor V.\} and Stefan Weiss and Yiorkas, \{Andrianos M.\} and Robin Young and Weihua Zhang and Barnes, \{Michael R.\} and Cabrera, \{Claudia P.\} and He Gao and Michael Boehnke and Eric Boerwinkle and Chambers, \{John C.\} and Connell, \{John M.\} and Christensen, \{Cramer K.\} and \{de Boer\}, \{Rudolf A.\} and Deary, \{Ian J.\} and George Dedoussis and Panos Deloukas and Dominiczak, \{Anna F.\} and Marcus Dorr and Roby Joehanes and Edwards, \{Todd L.\} and Tonu Esko and Myriam Fornage and Nora Franceschini and Franks, \{Paul W.\} and Giovanni Gambaro and Leif Groop and Goran Hallmans and Torben Hansen and Caroline Hayward and Oksa Heikki and Erik Ingelsson and Jaakko Tuomilehto and Marjo-Riitta Jarvelin and Kardia, \{Sharon L. R.\} and Fredrik Karpe and Kooner, \{Jaspal S.\} and Lakka, \{Timo A.\} and Claudia Langenberg and Lars Lind and Loos, \{Ruth J. F.\} and Markku Laakso and McCarthy, \{Mark I.\} and Olle Melander and Mohlke, \{Karen L.\} and Moris, \{Andrwe P.\} and Palmer, \{Colin N. A.\} and Oluf Pedersen and Ozren Polasek and Poulter, \{Neil R.\} and Province, \{Michael A.\} and Psaty, \{Bruce M.\} and Ridker, \{Paul M.\} and Rotter, \{Jerome I.\} and Igor Rudan and Veikko Salomaa and Samani, \{Nilesh J.\} and Sever, \{Peter J.\} and Tea Skaaby and Stafford, \{Jeanette M.\} and Starr, \{John M.\} and \{van der Harst\}, Pim and \{van der Meer\}, Peter and \{van Duijn\}, \{Cornelia M.\} and Anne-Claire Vergnaud and Vilmundur Gudnason and Wareham, \{Nicholas J.\} and Wilson, \{James G.\} and Willer, \{Cristen J.\} and Witte, \{Daniel R.\} and Eleftheria Zeggini and Danish Saleheen and Butterworth, \{Adam S.\} and John Danesh and Asselbergs, \{Folkert W.\} and Wain, \{Louise V.\} and Ehret, \{Georg B.\} and Chasman, \{Daniel I.\} and Caulfield, \{Mark J.\} and Paul Elliott and Lindgren, \{Cecilia M.\} and Daniel Levy and Christopher Newton-Cheh and Munroe, \{Patricia B.\} and Howson, \{Joanna M. M.\}",

year = "2017",

doi = "10.1161/CIRCGENETICS.117.001778",

language = "American English",

volume = "10",

journal = "CIRCULATION-CARDIOVASCULAR GENETICS",

issn = "1942-325X",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "5",

}

Kraja, AT, Cook, JP, Warren, HR, Surendran, P, Liu, C, Evangelou, E, Manning, AK, Grarup, N, Drenos, F, Sim, X, Smith, AV, Amin, N, Blakemore, AIF, Bork-Jensen, J, Brandslund, I, Farmaki, A-E, Fava, C, Ferreira, T, Herzig, K-H, Giri, A, Giulianini, F, Grove, ML, Guo, X, Harris, SE, Have, CT, Havulinna, AS, Zhang, H, Jorgensen, ME, Karajamaki, A, Kooperberg, C, Linneberg, A, Little, L, Liu, Y, Bonnycastle, LL, Lu, Y, Magi, R, Mahajan, A, Malerba, G, Marioni, RE, Mei, H, Menni, C, Morrison, AC, Padmanabhan, S, Palmas, W, Poveda, A, Rauramaa, R, Rayner, NW, Riaz, M, Rice, K, Richard, MA, Smith, JA, Southam, L, Stancakova, A, Stirrups, KE, Tragante, V, Tuomi, T, Tzoulald, I, Varga, TV, Weiss, S, Yiorkas, AM, Young, R, Zhang, W, Barnes, MR, Cabrera, CP, Gao, H, Boehnke, M, Boerwinkle, E, Chambers, JC, Connell, JM, Christensen, CK, de Boer, RA, Deary, IJ, Dedoussis, G, Deloukas, P, Dominiczak, AF, Dorr, M, Joehanes, R, Edwards, TL, Esko, T, Fornage, M, Franceschini, N, Franks, PW, Gambaro, G, Groop, L, Hallmans, G, Hansen, T, Hayward, C, Heikki, O, Ingelsson, E, Tuomilehto, J, Jarvelin, M-R, Kardia, SLR, Karpe, F, Kooner, JS, Lakka, TA, Langenberg, C, Lind, L, Loos, RJF, Laakso, M, McCarthy, MI, Melander, O, Mohlke, KL, Moris, AP, Palmer, CNA, Pedersen, O, Polasek, O, Poulter, NR, Province, MA, Psaty, BM, Ridker, PM, Rotter, JI, Rudan, I, Salomaa, V, Samani, NJ, Sever, PJ, Skaaby, T, Stafford, JM, Starr, JM, van der Harst, P, van der Meer, P, van Duijn, CM, Vergnaud, A-C, Gudnason, V, Wareham, NJ, Wilson, JG, Willer, CJ, Witte, DR, Zeggini, E, Saleheen, D, Butterworth, AS, Danesh, J, Asselbergs, FW, Wain, LV, Ehret, GB, Chasman, DI, Caulfield, MJ, Elliott, P, Lindgren, CM, Levy, D, Newton-Cheh, C, Munroe, PB & Howson, JMM 2017, 'new blood pressure-associated loci identified in meta-analyses of 475000 individuals', CIRCULATION-CARDIOVASCULAR GENETICS, vol. 10, no. 5. https://doi.org/10.1161/CIRCGENETICS.117.001778

TY - JOUR

T1 - new blood pressure-associated loci identified in meta-analyses of 475000 individuals

AU - Kraja, Aldi T.

AU - Cook, James P.

AU - Warren, Helen R.

AU - Surendran, Praveen

AU - Liu, Chunyu

AU - Evangelou, Evangelos

AU - Manning, Alisa K.

AU - Grarup, Niels

AU - Drenos, Fotios

AU - Sim, Xueling

AU - Smith, Albert Vernon

AU - Amin, Najaf

AU - Blakemore, Alexandra I. F.

AU - Bork-Jensen, Jette

AU - Brandslund, Ivan

AU - Farmaki, Aliki-Eleni

AU - Fava, Cristiano

AU - Ferreira, Teresa

AU - Herzig, Karl-Heinz

AU - Giri, Ayush

AU - Giulianini, Franco

AU - Grove, Megan L.

AU - Guo, Xiuqing

AU - Harris, Sarah E.

AU - Have, Christian T.

AU - Havulinna, Aki S.

AU - Zhang, He

AU - Jorgensen, Marit E.

AU - Karajamaki, AnneMari

AU - Kooperberg, Charles

AU - Linneberg, Allan

AU - Little, Louis

AU - Liu, Yongmei

AU - Bonnycastle, Lori L.

AU - Lu, Yingchang

AU - Magi, Reedik

AU - Mahajan, Anubha

AU - Malerba, Giovanni

AU - Marioni, Riccardo E.

AU - Mei, Hao

AU - Menni, Cristina

AU - Morrison, Alanna C.

AU - Padmanabhan, Sandosh

AU - Palmas, Walter

AU - Poveda, Alaitz

AU - Rauramaa, Rainer

AU - Rayner, Nigel William

AU - Riaz, Muhammad

AU - Rice, Ken

AU - Richard, Melissa A.

AU - Smith, Jennifer A.

AU - Southam, Lorraine

AU - Stancakova, Alena

AU - Stirrups, Kathleen E.

AU - Tragante, Vinicius

AU - Tuomi, Tiinamaija

AU - Tzoulald, Ioanna

AU - Varga, Tibor V.

AU - Weiss, Stefan

AU - Yiorkas, Andrianos M.

AU - Young, Robin

AU - Zhang, Weihua

AU - Barnes, Michael R.

AU - Cabrera, Claudia P.

AU - Gao, He

AU - Boehnke, Michael

AU - Boerwinkle, Eric

AU - Chambers, John C.

AU - Connell, John M.

AU - Christensen, Cramer K.

AU - de Boer, Rudolf A.

AU - Deary, Ian J.

AU - Dedoussis, George

AU - Deloukas, Panos

AU - Dominiczak, Anna F.

AU - Dorr, Marcus

AU - Joehanes, Roby

AU - Edwards, Todd L.

AU - Esko, Tonu

AU - Fornage, Myriam

AU - Franceschini, Nora

AU - Franks, Paul W.

AU - Gambaro, Giovanni

AU - Groop, Leif

AU - Hallmans, Goran

AU - Hansen, Torben

AU - Hayward, Caroline

AU - Heikki, Oksa

AU - Ingelsson, Erik

AU - Tuomilehto, Jaakko

AU - Jarvelin, Marjo-Riitta

AU - Kardia, Sharon L. R.

AU - Karpe, Fredrik

AU - Kooner, Jaspal S.

AU - Lakka, Timo A.

AU - Langenberg, Claudia

AU - Lind, Lars

AU - Loos, Ruth J. F.

AU - Laakso, Markku

AU - McCarthy, Mark I.

AU - Melander, Olle

AU - Mohlke, Karen L.

AU - Moris, Andrwe P.

AU - Palmer, Colin N. A.

AU - Pedersen, Oluf

AU - Polasek, Ozren

AU - Poulter, Neil R.

AU - Province, Michael A.

AU - Psaty, Bruce M.

AU - Ridker, Paul M.

AU - Rotter, Jerome I.

AU - Rudan, Igor

AU - Salomaa, Veikko

AU - Samani, Nilesh J.

AU - Sever, Peter J.

AU - Skaaby, Tea

AU - Stafford, Jeanette M.

AU - Starr, John M.

AU - van der Harst, Pim

AU - van der Meer, Peter

AU - van Duijn, Cornelia M.

AU - Vergnaud, Anne-Claire

AU - Gudnason, Vilmundur

AU - Wareham, Nicholas J.

AU - Wilson, James G.

AU - Willer, Cristen J.

AU - Witte, Daniel R.

AU - Zeggini, Eleftheria

AU - Saleheen, Danish

AU - Butterworth, Adam S.

AU - Danesh, John

AU - Asselbergs, Folkert W.

AU - Wain, Louise V.

AU - Ehret, Georg B.

AU - Chasman, Daniel I.

AU - Caulfield, Mark J.

AU - Elliott, Paul

AU - Lindgren, Cecilia M.

AU - Levy, Daniel

AU - Newton-Cheh, Christopher

AU - Munroe, Patricia B.

AU - Howson, Joanna M. M.

PY - 2017

Y1 - 2017

N2 - Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results— Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant ( P

AB - Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results— Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant ( P

U2 - 10.1161/CIRCGENETICS.117.001778

DO - 10.1161/CIRCGENETICS.117.001778

M3 - Article

SN - 1942-325X

VL - 10

JO - CIRCULATION-CARDIOVASCULAR GENETICS

JF - CIRCULATION-CARDIOVASCULAR GENETICS

IS - 5

ER -

new blood pressure-associated loci identified in meta-analyses of 475000 individuals

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