Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

Hend Alqaderi; Ebaa Al-Ozairi; Saadoun Bin-Hasan; Mary Tavares; Jo M. Goodson; Aishah Alsumait; Mohamed Abu-Farha; Jehad Abubaker; Sriraman Devarajan; Nourah Almuhana; Fahd Al-Mulla

doi:10.2217/bmm-2020-0282

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

Hend Alqaderi, Ebaa Al-Ozairi, Saadoun Bin-Hasan, Mary Tavares, Jo M. Goodson, Aishah Alsumait, Mohamed Abu-Farha, Jehad Abubaker, Sriraman Devarajan, Nourah Almuhana, Fahd Al-Mulla

Dasman Diabetes Institute

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

Original language	English
Pages (from-to)	1427-1437
Number of pages	11
Journal	Biomarkers in Medicine
Volume	14
Issue number	15
DOIs	https://doi.org/10.2217/bmm-2020-0282
State	Published - Oct 2020

Keywords

adolescents
C-reactive protein
diabetes
hyperglycemia
obesity
prevention

Funding Agency

Kuwait Foundation for the Advancement of Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/bmm-2020-0282

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Alqaderi, H., Al-Ozairi, E., Bin-Hasan, S., Tavares, M., Goodson, J. M., Alsumait, A., Abu-Farha, M., Abubaker, J., Devarajan, S., Almuhana, N., & Al-Mulla, F. (2020). Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents. Biomarkers in Medicine, 14(15), 1427-1437. https://doi.org/10.2217/bmm-2020-0282

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title = "Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents",

abstract = "Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.",

keywords = "adolescents, C-reactive protein, diabetes, hyperglycemia, obesity, prevention",

author = "Hend Alqaderi and Ebaa Al-Ozairi and Saadoun Bin-Hasan and Mary Tavares and Goodson, {Jo M.} and Aishah Alsumait and Mohamed Abu-Farha and Jehad Abubaker and Sriraman Devarajan and Nourah Almuhana and Fahd Al-Mulla",

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year = "2020",

month = oct,

doi = "10.2217/bmm-2020-0282",

language = "English",

volume = "14",

pages = "1427--1437",

journal = "Biomarkers in Medicine",

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Alqaderi, H , Al-Ozairi, E, Bin-Hasan, S, Tavares, M, Goodson, JM, Alsumait, A, Abu-Farha, M , Abubaker, J, Devarajan, S, Almuhana, N & Al-Mulla, F 2020, 'Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents', Biomarkers in Medicine, vol. 14, no. 15, pp. 1427-1437. https://doi.org/10.2217/bmm-2020-0282

TY - JOUR

T1 - Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

AU - Alqaderi, Hend

AU - Al-Ozairi, Ebaa

AU - Bin-Hasan, Saadoun

AU - Tavares, Mary

AU - Goodson, Jo M.

AU - Alsumait, Aishah

AU - Abu-Farha, Mohamed

AU - Abubaker, Jehad

AU - Devarajan, Sriraman

AU - Almuhana, Nourah

AU - Al-Mulla, Fahd

PY - 2020/10

Y1 - 2020/10

N2 - Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

AB - Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

KW - adolescents

KW - C-reactive protein

KW - diabetes

KW - hyperglycemia

KW - obesity

KW - prevention

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U2 - 10.2217/bmm-2020-0282

DO - 10.2217/bmm-2020-0282

M3 - Article

C2 - 33151093

AN - SCOPUS:85096203190

SN - 1752-0363

VL - 14

SP - 1427

EP - 1437

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 15

ER -

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

Abstract

Keywords

Funding Agency

UN SDGs

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