TY - JOUR
T1 - Ketoacidosis at first presentation of type 1 diabetes mellitus among children
T2 - A study from Kuwait
AU - Shaltout, Azza Aly
AU - Channanath, Arshad Mohamed
AU - Thanaraj, Thangavel Alphonse
AU - Omar, Dina
AU - Abdulrasoul, Majedah
AU - Zanaty, Nabila
AU - Almahdi, Maria
AU - Alkandari, Hessa
AU - Alabdulrazzaq, Dalia
AU - D'Mello, Linda
AU - Mandani, Fawziya
AU - Alanezi, Ayed
AU - AlBasiry, Eman
AU - Alkhawari, M.
PY - 2016/6/22
Y1 - 2016/6/22
N2 - We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children and adolescents (0-14 years) at diagnosis of Type 1 Diabetes Mellitus (T1DM) in Kuwait. Between 1st January 2011 and 31st December 2013, all newly diagnosed children with diabetes were registered prospectively in a population-based electronic register. DKA was diagnosed using standard criteria based on the levels of venous pH and serum bicarbonate. At the time of diagnosis, mild/moderate DKA was present in 24.8% of the children, while severe DKA was present in 8.8%. Incidence of ketoacidosis was significantly higher in young children less than 2 (60.7% vs 32.4% p = <0.005) compared to children 2-14 years old, and a higher proportion presented with severe DKA (21.4% vs 8.3% p = <0.05). No association was seen with gender. Significant differences were found in the incidence of DKA between Kuwaiti and non-Kuwaiti children (31.1% vs 39.8%; p < 0.05). Family history of diabetes had a protective effect on the occurrence of DKA (OR = 0.44; 95% CI = 0.27-0.71). Incidence of DKA in children at presentation of T1DM remains high at 33.6%. Prevention campaigns are needed to increase public awareness among health care providers, parents and school teachers in Kuwait.
AB - We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children and adolescents (0-14 years) at diagnosis of Type 1 Diabetes Mellitus (T1DM) in Kuwait. Between 1st January 2011 and 31st December 2013, all newly diagnosed children with diabetes were registered prospectively in a population-based electronic register. DKA was diagnosed using standard criteria based on the levels of venous pH and serum bicarbonate. At the time of diagnosis, mild/moderate DKA was present in 24.8% of the children, while severe DKA was present in 8.8%. Incidence of ketoacidosis was significantly higher in young children less than 2 (60.7% vs 32.4% p = <0.005) compared to children 2-14 years old, and a higher proportion presented with severe DKA (21.4% vs 8.3% p = <0.05). No association was seen with gender. Significant differences were found in the incidence of DKA between Kuwaiti and non-Kuwaiti children (31.1% vs 39.8%; p < 0.05). Family history of diabetes had a protective effect on the occurrence of DKA (OR = 0.44; 95% CI = 0.27-0.71). Incidence of DKA in children at presentation of T1DM remains high at 33.6%. Prevention campaigns are needed to increase public awareness among health care providers, parents and school teachers in Kuwait.
UR - http://www.scopus.com/inward/record.url?scp=84975733129&partnerID=8YFLogxK
U2 - 10.1038/srep27519
DO - 10.1038/srep27519
M3 - Article
C2 - 27328757
AN - SCOPUS:84975733129
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 27519
ER -
