TY - JOUR
T1 - Histopathological observations on organs from rabbits injected with the skin toxin of the Arabian Gulf catfish (Arius bilineatus, Valenciennes)
AU - Alnaqeeb, M. A.
AU - Al-Hassan, J. M.
AU - Ali, M.
AU - Thomson, M.
AU - Criddle, R. S.
PY - 1989
Y1 - 1989
N2 - M. A. Alnaqeeb, J. M. Al-Hassan, M. Ali, M. Thomson and R. S. Criddle. Histopathological observations on organs from rabbits injected with the skin toxin of the Arabian Gulf catfish (Arius bilineatus, Valenciennes). Toxicon 27, 789-795, 1989.-Toxicity of soluble protein extracts (skin toxin) from epidermal skin secretions of the catfish, Arius bilineatus (previously identified as Arius thalassinus), was examined in rabbits. Intravenous injections containing doses as low as 2 mg protein/kg body weight caused mortality in most animals tested. Histopathological examination of lung, heart, liver and kidney tissues of rabbits injected with skin toxin indicated that the lungs and livers of treated animals were adversely affected, while heart and kidney tissues appeared to be normal. Lethality of skin toxin was prevented by pretreatment of the rabbits with indomethacin. Histopathological examination of lung and liver tissues of indomethacin pretreated animals showed a significant reduction in the damage observed after injection of skin toxin.
AB - M. A. Alnaqeeb, J. M. Al-Hassan, M. Ali, M. Thomson and R. S. Criddle. Histopathological observations on organs from rabbits injected with the skin toxin of the Arabian Gulf catfish (Arius bilineatus, Valenciennes). Toxicon 27, 789-795, 1989.-Toxicity of soluble protein extracts (skin toxin) from epidermal skin secretions of the catfish, Arius bilineatus (previously identified as Arius thalassinus), was examined in rabbits. Intravenous injections containing doses as low as 2 mg protein/kg body weight caused mortality in most animals tested. Histopathological examination of lung, heart, liver and kidney tissues of rabbits injected with skin toxin indicated that the lungs and livers of treated animals were adversely affected, while heart and kidney tissues appeared to be normal. Lethality of skin toxin was prevented by pretreatment of the rabbits with indomethacin. Histopathological examination of lung and liver tissues of indomethacin pretreated animals showed a significant reduction in the damage observed after injection of skin toxin.
UR - https://www.scopus.com/pages/publications/0024354073
U2 - 10.1016/0041-0101(89)90046-9
DO - 10.1016/0041-0101(89)90046-9
M3 - Article
C2 - 2781579
AN - SCOPUS:0024354073
SN - 0041-0101
VL - 27
SP - 789
EP - 795
JO - Toxicon
JF - Toxicon
IS - 7
ER -