TY - JOUR
T1 - Glycolaldehyde induces apoptosis in a human breast cancer cell line
AU - Al-Maghrebi, May A.
AU - Al-Mulla, Fahd
AU - Benov, Ludmil T.
N1 - Funding Information:
The authors thank Anis F. Beema and Fatima Sequeira for their technical assistance. This work was supported by Grants MB031 and MB01/01 from Kuwait University and Grant 990707 from the Kuwait Foundation for the Advancement of Science (KFAS).
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because α-hydroxy and α,β-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity.
AB - Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because α-hydroxy and α,β-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity.
KW - Anti-tumor activity of glycolaldehyde
KW - Apoptosis
KW - Breast cancer
KW - Glycolaldehyde
KW - Superoxide dismutase
UR - https://www.scopus.com/pages/publications/0042062295
U2 - 10.1016/S0003-9861(03)00334-5
DO - 10.1016/S0003-9861(03)00334-5
M3 - Article
C2 - 12921788
AN - SCOPUS:0042062295
SN - 0003-9861
VL - 417
SP - 123
EP - 127
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -
