Abstract
Targeting biotin receptors in cancer cells can improve specifying of photosensitizers (PSs) for cancer treatment by photodynamic therapy (PDT) applications. Consequently, there has been extensive research focusing mainly on the design of PSs with optimized pharmaceutical properties and better targeting toward cancer cells. Herein a tailored mono-biotinylated zinc(II) phthalocyanine (Pc-1) substituted with six phenoxy-bis(triazolyl) substituents has been synthesized. This Pc-1 has been further modified to its cationic version (Pc-2) through quaternizing of the triazole moiety to gain water solubility. Both non-ionic zinc(II) phthalocyanine (Pc-1) and its cationic derivative (Pc-2) were characterized by standard spectroscopic techniques, namely; FT-IR, 1H and 13C NMR, UV-Vis and MALDI-TOF, and by elemental analysis. The photophysical and photochemical properties were evaluated in DMSO for the non-ionic Pc-1 and in both DMSO and water for the cationic Pc-2.
| Original language | English |
|---|---|
| Title of host publication | Porphyrin Science By Women (In 3 Volumes) |
| Publisher | World Scientific Publishing Co. |
| Pages | 587-596 |
| Number of pages | 10 |
| ISBN (Electronic) | 9789811223556 |
| DOIs | |
| State | Published - 1 Jan 2020 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Photochemical
- Photodynamic therapy (PDT)
- Photophysical
- Photosensitizer (PS)
- Phthalocyanine (PC)
Funding Agency
- Kuwait Foundation for the Advancement of Sciences
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