A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

Aishah Al-Jarallah; Bernardo L. Trigatti

doi:10.1016/j.bbalip.2010.08.006

A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

Aishah Al-Jarallah, Bernardo L. Trigatti

Kuwait University

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

High density lipoprotein (HDL) levels are inversely proportional to the risk of coronary heart disease. HDL mediates various anti-atherogenic pathways including reverse cholesterol transport from cells of the arterial wall to the liver and steroidogenic tissues. In addition HDL activates various intracellular signaling events that confer atheroprotection. The HDL receptor, scavenger receptor class B type I (SR-BI) has been implicated directly and indirectly in HDL induced signaling. The aim of this review is to summarize the role of SR-BI in HDL induced signaling in the vasculature.

Original language	English
Pages (from-to)	1239-1248
Number of pages	10
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1801
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2010.08.006
State	Published - Dec 2010

Keywords

Atheroprotection
Caveolae
Cholesterol
HDL
S1PR
Signaling
Sphingosine-1-phosphate
SR-BI

Funding Agency

Kuwait Foundation for the Advancement of Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbalip.2010.08.006

Cite this

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title = "A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways",

abstract = "High density lipoprotein (HDL) levels are inversely proportional to the risk of coronary heart disease. HDL mediates various anti-atherogenic pathways including reverse cholesterol transport from cells of the arterial wall to the liver and steroidogenic tissues. In addition HDL activates various intracellular signaling events that confer atheroprotection. The HDL receptor, scavenger receptor class B type I (SR-BI) has been implicated directly and indirectly in HDL induced signaling. The aim of this review is to summarize the role of SR-BI in HDL induced signaling in the vasculature.",

keywords = "Atheroprotection, Caveolae, Cholesterol, HDL, S1PR, Signaling, Sphingosine-1-phosphate, SR-BI",

author = "Aishah Al-Jarallah and Trigatti, \{Bernardo L.\}",

note = "Funding Information: Sources of Funding: Research in our lab is supported by grants from the Canadian Institutes of Health Research ( MOP74753 ) and the Heart and Stroke Foundation of Ontario ( NA6310 ) to BLT. The Atherothrombosis Research Group is funded by a Program Grant ( PRG 6502 ) from the Heart and Stroke Foundation of Ontario . AA is a recipient of a graduate scholarship from Kuwait University, Faculty of Medicine. ",

year = "2010",

month = dec,

doi = "10.1016/j.bbalip.2010.08.006",

language = "English",

volume = "1801",

pages = "1239--1248",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

issn = "1388-1981",

publisher = "Elsevier B.V.",

number = "12",

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TY - JOUR

T1 - A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

AU - Al-Jarallah, Aishah

AU - Trigatti, Bernardo L.

N1 - Funding Information: Sources of Funding: Research in our lab is supported by grants from the Canadian Institutes of Health Research ( MOP74753 ) and the Heart and Stroke Foundation of Ontario ( NA6310 ) to BLT. The Atherothrombosis Research Group is funded by a Program Grant ( PRG 6502 ) from the Heart and Stroke Foundation of Ontario . AA is a recipient of a graduate scholarship from Kuwait University, Faculty of Medicine.

PY - 2010/12

Y1 - 2010/12

N2 - High density lipoprotein (HDL) levels are inversely proportional to the risk of coronary heart disease. HDL mediates various anti-atherogenic pathways including reverse cholesterol transport from cells of the arterial wall to the liver and steroidogenic tissues. In addition HDL activates various intracellular signaling events that confer atheroprotection. The HDL receptor, scavenger receptor class B type I (SR-BI) has been implicated directly and indirectly in HDL induced signaling. The aim of this review is to summarize the role of SR-BI in HDL induced signaling in the vasculature.

AB - High density lipoprotein (HDL) levels are inversely proportional to the risk of coronary heart disease. HDL mediates various anti-atherogenic pathways including reverse cholesterol transport from cells of the arterial wall to the liver and steroidogenic tissues. In addition HDL activates various intracellular signaling events that confer atheroprotection. The HDL receptor, scavenger receptor class B type I (SR-BI) has been implicated directly and indirectly in HDL induced signaling. The aim of this review is to summarize the role of SR-BI in HDL induced signaling in the vasculature.

KW - Atheroprotection

KW - Caveolae

KW - Cholesterol

KW - HDL

KW - S1PR

KW - Signaling

KW - Sphingosine-1-phosphate

KW - SR-BI

UR - https://www.scopus.com/pages/publications/77957941762

U2 - 10.1016/j.bbalip.2010.08.006

DO - 10.1016/j.bbalip.2010.08.006

M3 - Review article

C2 - 20732452

AN - SCOPUS:77957941762

SN - 1388-1981

VL - 1801

SP - 1239

EP - 1248

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

ER -

A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

Abstract

Keywords

Funding Agency

UN SDGs

Access to Document

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