Advanced treatments of obstructive sleep apnea and its impact on obesity

Obstructive sleep apnea (OSA) is associated with many health problems such as obesity, diabetes and CVD. OSA is often ignored and goes undiagnosed due to unavailability of sleep laboratories and lack of awareness about the danger of OSA. There are different classes of obstructive sleep apnea ranging from
mild to severe. OSA can be treated through a number of procedures like Positional Therapy (PT), Mandibular Advancement Device (MAD), Continuous Positive Airway Pressure (CPAP), ENT Surgery, Upper Airway Stimulation (UAS), and Maxillofacial Surgery (MMA). The effect of treatment can be established by
repeated sleep studies. Using known and newly discovered biomarkers in DDI, we will assess the efficacies of different treatment approaches in treating OSA and propose a model for the ideal interventional methods against disease severity. A total of 400 patients will be included. CPAP: N=100; maxillofacial
surgery: N=50; upper airway stimulation: N=50; oral appliances: N=100; PT: N=100; and controls: N=100.