Project Details
Abstract English
"The rate of cardiovascular disease prevalence increases progressively with age. Due to population ageing,
increased incidence of cardiovascular disease is expected to rise significantly with inevitable social and economic
burdens on the society. It is also known that genetic and environmental factors play an important role and is
closely linked to increased risk of cardiovascular diseases. In addition to those factors, the prevailing theory
is that shortness and deterioration and attrition of the chromosome ends, which are caused by high levels
of oxidization, may lead to endothelial vessel dysfunction associated with myocardial infarction. This study
examines the link between the length of the chromosome ends and telomeres activity and acute myocardial
infarction. The study involves 200 patients with acute myocardial infarction and 200 individuals with apparent
normal health. Anthropometric measures will be used to identify obesity indicators. Chemical analysis will
measure levels of adiponectin, insulin, sugar and steroids. The quantification of the length of the chromosome
ends and telomeres activity will be completed by using polymerization chain reaction. Given the high rates of
obesity and heart diseases, we should be able to find a link between obesity and its related disease incidences
and deterioration and attrition to the chromosome ends based on the evidence accumulated from animal and
epidemiological studies. If the study is able to prove the biological link between obesity and its related disease
incidences, such as acute myocardial infarction, and chromosome ends, it will pave the way to new therapeutic
or preventive strategies."
increased incidence of cardiovascular disease is expected to rise significantly with inevitable social and economic
burdens on the society. It is also known that genetic and environmental factors play an important role and is
closely linked to increased risk of cardiovascular diseases. In addition to those factors, the prevailing theory
is that shortness and deterioration and attrition of the chromosome ends, which are caused by high levels
of oxidization, may lead to endothelial vessel dysfunction associated with myocardial infarction. This study
examines the link between the length of the chromosome ends and telomeres activity and acute myocardial
infarction. The study involves 200 patients with acute myocardial infarction and 200 individuals with apparent
normal health. Anthropometric measures will be used to identify obesity indicators. Chemical analysis will
measure levels of adiponectin, insulin, sugar and steroids. The quantification of the length of the chromosome
ends and telomeres activity will be completed by using polymerization chain reaction. Given the high rates of
obesity and heart diseases, we should be able to find a link between obesity and its related disease incidences
and deterioration and attrition to the chromosome ends based on the evidence accumulated from animal and
epidemiological studies. If the study is able to prove the biological link between obesity and its related disease
incidences, such as acute myocardial infarction, and chromosome ends, it will pave the way to new therapeutic
or preventive strategies."
| Status | Finished |
|---|---|
| Effective start/end date | 1/04/14 → 9/07/17 |
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