Continuous Arterio-Venous Hemofiltration and Exchange Transfusion in Experimentally Induced Septicemia in Swine

كان الهدف من البحث إيجاد وسيلة سهلة وعملية لمساعدة المرضى المصابين بتجرثم الدم، وذلك من خلال تجربة مختبرية بترشيح دم الخنازير بواسطة فلتر خاص لفصل بعض السوائل التي قد يكون لها دخل مباشر على صحة الحيوان وشفائه وتقوية الجهاز المناعي لديه. بالرغم من التقدم الكبير في الطب إلا ان هناك الكثير من الوفيات التي تنتج عن اصابة المرضى بالجراثيم المختلفة وخاصة المتعلقة بتجرثم الدم. اهتمت الدراسة بإزالة بعض المواد الناتجة عن هذه الاصابة والتي تسبب اضرارا بالغة في بعض أنظمة الجسم المهمة. وقد تم استخدام فلاتر خاصة بنقل الدم الكامل ليعوض الجسم بالمواد المهمة للمناعة وذلك بعد إزالتها بواسطة عملية الفلترة. وبهذا تُمكن من مساعدة المريض في التغلب على اصابته بتجرثم الدم.

Using ultrafiltration in the model of sepsis. Evaluating effects of hemofiltration on cardiorespiratory performance. Sepsis is a multi-factorial disease process which results in multi-organ system injury and dysfunction. These injuries are mediated by harmful immuno-modulators, including cytokines and interleukins which are released during sepsis. The purpose of this study was to examine the adverse effects of sepsis on cardiorespiratory function and to determine if ultrafiltration improves cardiorespiratory function. One approach to hemofiltration utilizes whole blood as a replacement fluid. Whole blood provides several important mediators that are removed during ultrafiltration. Therefore, an additional purpose of this study was to evaluate the effects of hemofiltration and whole blood transfusion on cardio-respiratory performance. Despite recent advances in medicine, patients who develop serious infections frequently die. This is a result of the infections and alterations that they cause in other organs. One way to help treat these infections is by “cleaning” the blood through the use of filter. While this has been done in the case of other diseases, it has not been used for patients with infections. In addition to removing fluid by the filter and replacing the removed fluid with whole blood which can better fight the infection, it may reverse this process. Data was collected at pre-sepsis, post-sepsis induction and at 30, 60, 120 and 180 minutes after sepsis induction. The data from the three groups were compared using two-way analysis of variance with repeated measures. Data obtained from this project will enable in developing new techniques that will help patients with serious infections.