Project Details
Abstract English
Background & Aims: The purpose of this study is to investigate the prokinetic (motility -increasing) effect of erythromycin in human and sheep gallbladders.
Methods: In vitro isometric tension recording in organ baths of gallbladder strips from the fundus after addition of erythromycin and sheep duodenal extract before and after treatment with erythromycin.
Expected output: To establish the prokinetic mechanism of action of erythromycin and to investigate if erythromycin itself elicits gallbladder contraction or induces the release of a motility enhancing subtance from duodenal rings incubated with erythromycin 1 0 -5 M) in Krebs-buffer. Blocking experiments with atropine, 5HT3 ( 1 0 -6 M) blockers a n d somatostatin in organ baths and in the incubating fluid to establish what induces (1 ) the release in the duodenum and (2) the contraction in the gfallbladder smooth muscle
Methods: In vitro isometric tension recording in organ baths of gallbladder strips from the fundus after addition of erythromycin and sheep duodenal extract before and after treatment with erythromycin.
Expected output: To establish the prokinetic mechanism of action of erythromycin and to investigate if erythromycin itself elicits gallbladder contraction or induces the release of a motility enhancing subtance from duodenal rings incubated with erythromycin 1 0 -5 M) in Krebs-buffer. Blocking experiments with atropine, 5HT3 ( 1 0 -6 M) blockers a n d somatostatin in organ baths and in the incubating fluid to establish what induces (1 ) the release in the duodenum and (2) the contraction in the gfallbladder smooth muscle
| Status | Finished |
|---|---|
| Effective start/end date | 1/11/97 → 1/11/98 |
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